Advanced Practice Locums January 27, 2026

10 Career Paths for Physician Assistants

The role of a physician assistant (PA) is one of the most versatile in healthcare. Unlike many medical specializations that lock you onto a single track, PAs have the unique ability to pivot between specialties throughout their careers. This flexibility is a huge draw for professionals who crave variety or want to evolve their practice as their interests change.

If you are exploring new physician assistant jobs or just starting your journey, understanding the landscape of opportunities available is important. From the high-energy environment of the emergency room to the precision of the operating theater, here are 10 different career options for physician assistants.

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1. Orthopedic Surgery

Orthopedics is consistently one of the most popular specialties for PAs. In this role, you work closely with surgeons to treat musculoskeletal injuries and diseases. Your day might involve assisting in surgery, casting fractures, or managing post-operative care. It is a hands-on specialty that often yields immediate, tangible results for patients, making it highly rewarding.

2. Emergency Medicine

For those who thrive on adrenaline and fast-paced environments, emergency medicine is a top choice. Emergency medicine PAs are often the first line of defense, assessing and treating a wide range of acute illnesses and injuries. You need to be a quick thinker and comfortable with a variety of procedures. This role offers diverse experiences—no two shifts are ever the same.

3. Family Medicine

If you prefer building long-term relationships with patients, family medicine might be your calling. Family medicine PAs provide comprehensive care for individuals and families across all ages. You handle everything from routine check-ups and immunizations to managing chronic conditions like diabetes. This specialty is the backbone of primary care and allows for a broad scope of practice.

4. General Surgery

General surgery PA jobs place you right in the operating room. You act as the surgeon's first assistant during procedures and handle much of the pre- and post-operative management. This role requires a high level of technical skill and the ability to work well under pressure. It serves as an excellent foundation for PAs interested in surgical sub-specialties later in their careers.

5. Cardiothoracic Surgery

This is a highly specialized and demanding field focusing on the heart, lungs, and other thoracic organs. Cardiothoracic PAs assist in complex surgeries like bypasses and valve replacements. Because of the critical nature of these procedures, this specialty often commands higher compensation.

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6. Dermatology

Dermatology PAs diagnose and treat skin conditions ranging from acne and eczema to skin cancer. They also perform cosmetic procedures like Botox and laser treatments. This specialty often offers a more predictable schedule compared to surgery or emergency medicine, providing a great work-life balance while still offering the satisfaction of patient care.

7. Critical Care

Critical care PAs work in intensive care units (ICUs), managing patients with life-threatening conditions. This role demands a deep understanding of physiology and pharmacology. You will work with a multidisciplinary team to make split-second decisions for critically ill patients. It is intellectually challenging and emotionally intense work.

8. Oncology

Oncology PAs care for patients undergoing cancer treatment. This role involves conducting physical exams, ordering tests, and managing the side effects of chemotherapy or radiation. While it can be emotionally taxing, it is also profoundly meaningful work where you support patients and families through some of their most difficult times.

9. Women’s Health

Specializing in women’s health allows PAs to focus on reproductive and gynecological care. Responsibilities include performing pelvic exams, prescribing birth control, and providing prenatal care. This field allows PAs to empower women through education and preventative care, making a significant impact on community health.

10. Locum Tenens

If you aren't ready to commit to one location or specialty, locum tenens offers the ultimate flexibility. Locum tenens PAs fill temporary vacancies in hospitals and clinics across the country. This path allows you to travel, test out different specialties, and earn a premium salary. It’s an excellent way to gain diverse experience and find what truly fits your lifestyle.

Finding Your Perfect Fit

Whether you are drawn to the precision of surgery or the continuity of family practice, the market for physician assistant jobs is robust and growing. The beauty of the PA profession lies in your ability to shape your career to fit your life and interests.

If you are ready to explore these PA jobs, or perhaps consider a locum tenens adventure, AMN Healthcare can help connect you with roles that match your goals. From competitive salaries to sign-on bonuses and loan forgiveness, the right position is out there waiting for you.

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